Publications


REVIEW ARTICLES

 
  1. Phan, AT, Goldrath AW, Glass, CK.  Metabolic and Epigenic Coordination of T Cell and Macrophage Immunity.  2017. Immunity. 46(5):714-729. [Full Text] [PDF]
  2. Phan AT, Goldrath AW. Hypoxia-inducible Factors Regulate T cell Metabolism and Function. 2015. Molecular Immunology. 68(2 Pt C):527-35. [Full Text] [PDF]
  3. Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. 2014. Nature Immunology.  15(12):1104-1115. PMCID: PMC4386685. [Full Text] [PDF]
  4. Palazon A, Goldrath AW, Nizet V, Johnson RJ.  HIF transcription factors, inflammation and immunity. 2014.  Immunity. 41:518-528. PMCID: PMC4346319. [Full Text] [PDF]
  5. Omilusik KD, Shaw LA, Goldrath AW.  2013.  Remembering one’s ID/E-ntity: E/ID protein regulation of T cell memory.  Curr Opin Immunol. 25(5):660-6. [Full Text] [PDF]
  6. Hedrick SM, Hess MR, Doedens AL, Goldrath AW, Stone EL. 2012. FOXO transcription factors throughout T cell biology. Nature Reviews in Immunology. 12(9):649-61.  PMCID: PMC3875397. [Full Text] [PDF]
  7. D’Cruz LM, Yang CY, Goldrath AW. 2010. Transcriptional regulation of NKT cell development and homeostasis. Current Opinion in Immunology. 22(2):199-205. PMCID: PMC2854242. [Full Text] [PDF]
  8. D’Cruz LM, Rubinstein MP, Goldrath AW. 2009. Surviving the crash: transitioning from effector to memory CD8+ T cell. Seminars in Immunology. 21(2):92-8.  PMCID: PMC2671236. [Full Text] [PDF]
  9. Goldrath AW, Hedrick SM. 2005. Central Tolerance Matters. Immunity. 23(2):113-4. [Full Text] [PDF]
  10. Sivakumar PV, Goldrath AW, Brown S, Van der vuurst De vries AR, Viney J, Kennedy MK. 2002. IL-15: Insights from characterizing IL-15 knockout mice. Cytokine Knockouts, 2nd edition (Ed:Fantuzzi G), Humana Press, Totowa, NJ. 
  11. Goldrath AW. 2002.  Maintaining the status quo:  T-cell homeostasis. Microbes and Infection. 4(5):539-45. [Full Text] [PDF]
  12. Bevan MJ, Goldrath AW. 2000. T cell memory: you must remember this…Current Biology. 10(9):R338-40. [Full Text] [PDF]
  13. Goldrath AW, Bevan MJ. 1999. Selecting and maintaining a diverse T cell repertoire. Nature. 402(6759):255-62. [Full Text] [PDF]

Research Articles

 
  1. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. 2017. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nature Immunology. 18(5):573-582. [Full Text] [PDF]

  2. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. 2017. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nature Immunology. 18(4):422-432. [Full Text] [PDF]

  3. Phan, AT, Doedens AL, Palazon A, Tyrakis PA, Cheung KP, Johnson RJ, Goldrath AW. 2016. Constitutive glycolyitic metabolism supports CD8+ T cell effector memory differentiation during viral infection. Immunity. 45:1024-1037. [Full Text] [PDF]

  4. Tyrakis PA, Palazon A, Macias D., Lee KL, Phan AT, Velica P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS. 2016. S-2-hydorxyglutarate regulates CD8+ T-lymphocyte fate. Nature. 540:236-241. [Full Text] [PDF]

  5. Doedens AL, Rubinstein MP, Gross ET, Best JA, Craig DH, Baker MK, Bui JD, Goldrath AW. 2016. Molecular programming of tumor-infiltrating CD8++ T cells and IL-15 resistance.  Cancer Immunology Research. 4:799-811. [Full Text] [PDF]

  6. Clever D, Roychoudhuri R, Constantinides MG, Askenase MH, Sukumar M, Kebanoff CA, Eil RL, Hickman HD, Yu Z, Pan JH, Palmer DC, Phan AT, Goulding J, Gattinoni L, Goldrath AW, Belkaid Y, Restifo NP. 2016. Oxygen sensing by T cells establishes an immunologically tolerant metastatic niche. Cell. 166:1117-1131. [Full Text] [PDF]

  7. Shaw LA, Bélanger S, Omilusik KD, Cho S, Scott-Browne JP, Nance JP, Goulding J, Lasorella A, Lu LF, Crotty S, Goldrath AW. 2016. Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nature Immunology. 17(7): 834-43. PMCID: PMC4915968. [Full Text] [PDF]

  8. Stradner MH, Cheung KP, Lasorella A, Goldrath AW, D'Cruz LM. 2016. Id2 regulates hyporesponsive invariant natural killer T cells. Immunol Cell Biol. 2016. 19: PMID: 26880074 [Full Text] [PDF]

  9. Chea S, Schmutz S, Berthault C, Perchet T, Petit M, Burlen-Defranoux O, Goldrath AW, Rodewald HR, Cumano A, Golub R. 2016. Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling. Cell Rep. 4: 1500-16. PMCID:. [Full Text] [PDF]

  10. Almaden JV, Liu YC, Yang E, Otero D, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A.  2016. B cell survival and development controlled by the coordination of NFκB family members RelB and cRel.  Blood. 2016. Jan 14.  Pii: blood-2014-10-606988. Epub ahead of print.  [Full Text][PDF]

  11. Su EW, Moore CJ, Suriano S, Johnson CB, Songalia N, Patterson A, Neirzke DJ, Andrijauskaite K, Garrett-Mayer E, Mehrotra S, Paulos CM, Doedens AL, Goldrath AW, Li Z, Cole DJ, Rubinstein MP. IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy.  Science Translational Medicine.2015. 7 (311):311ra170. [Full Text] [PDF]
     
  12. Omilusik KD, Best JA, Yu B, Goossens S, Weidemann A, Nguyen JV, Seuntjens E, Stryjewska A, Zweier C, Roychoudhuri R, Gattinoni L, Bird LM, Higashi Y, Kondoh H, Huylebroeck D, Haigh J, AW Goldrath. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection. Journal of Experimental Medicine. 2015. 212(12): 2027-39. [Full Text] [PDF]
     
  13. Phan AT, Goldrath AW. Hypoxia-inducible Factors Regulate T cell Metabolism and Function. Molecular Immunology. 2015. 68(2 Pt C):527-35. [Full Text][PDF]
     
  14. Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Yin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM. ICOS coreceptor signaling inactivates the transcriptional factor FOXO1 to promote Tfh cell differentiation.  Immunity. 2015. 42(2):239-51. [Full Text] [PDF]
     
  15. Fulton RB, Hamilton SE, Xing Y, Best, JA, Goldrath AW, Hogquist KA, SC Jameson. The TCR’s sensitivity to self peptide-MHC dictates the ability of naïve CD8+ T cells to respond to foreign antigens. Nature Immunology. 2015. 16:107-117. [Full Text] [PDF]
     
  16. Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nature Immunology.  2014. 15(12):1104-1115. [Full Text] [PDF]
     
  17. Palazon A, Goldrath AW, Nizet V, Johnson RJ.  HIF transcription factors, inflammation and immunity. Immunity. 2014. 41:518-528. [Full Text] [PDF]
     
  18. D’Cruz LM, Stradner MH, Yang CY, Goldrath AW. E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.  J Immunol. 2014. 192(5):2227-36. [Full Text] [PDF]
     
  19. Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y, Fu X.  An effective approach to prevent immune rejection of human ESC-derived allografts.  Cell Stem Cell. 2014. 14(1): 121-30. [Full Text][PDF] 
     
  20. Rubinstein, M.P., Salem, M.L., Doedens, A., Rivell, G.L., Cole, D.J. and A.W. Goldrath. G-CSF/anti-GCSF mAb cytokine complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising the CD8+ T cell immune response. 2013. Journal of Hematology and Oncology. 6:75. [Full Text] [PDF] 
     
  21. Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chivers ER, Johnson RS.  HIF isoforms in the skin differentially regulate systemic arterial pressure.  Proc Natl Acad Sci USA. 2013. 110(43):17570-5. [Full Text] [PDF]
     
  22. Omilusik KD, Shaw LA, Goldrath AW.  Remembering one’s ID/E-ntity: E/ID protein regulation of T cell memory.  Curr Opin Immunol. 2013. 25(5):660-6. [Full Text] [PDF]
     
  23. Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW.  Hypoxia-Inducible Factors enhance CD8+ T cell effector responses to persistent antigen. Nature Immunology.  2013. Nature Immunology.  14(11):1172-82. [Full Text] [PDF]
     
  24. Saenz SA, Siracusa MC, Monticelli LA, Ziegler CG, Kim BS, Brestoff JR, Peterson LW, Wherry EJ, Goldrath AW, Bhandoola A, Artis D.  IL-25 simultaneously elicits distinct population of innate lymphoid cells and multi-potent progenitor type 2 cells.  Journal of Experimental Medicine. 2013. 210(9):1823-37. [Full Text] [PDF]
     
  25. Hess Michelini, R, Doedens, AL, Goldrath, AW, Hedrick SM. Differentiation of CD8 memory T cells depends on Foxo1. Journal of Experimental Medicine. 2013 210(6):1189-200.  [Full Text] [PDF]   
     
  26. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW; The Immunological Genome Project Consortium. Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation. Nature Immunology. 2013 14(4):404-12.  [Full Text] [PDF]   
     
  27. Knell J, Best JA, Lind NA, Yang E, D’Cruz LM, Goldrath AW. Id2 influences differentiation of Killer cell lectin-like receptor G1hi short-lived CD8+ effector T cells. Journal of Immunology. 2013 190(4):1501-09.  [Full Text] [PDF] 
     
  28. Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, LL Lanier; The Immunological Genome Project Consortium, Molecular definition of the identity and activation of natural killer cells.  Nature Immunology. 2012 13(10):1000-9.  [Full Text] [PDF]
     
  29. Li HS, Yang CY, Nallaparaju KC, Zhang H, Liu YJ, Goldrath AW, Watowich SS. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood. 2012 120(22):4363-73. [Full Text][PDF]
     
  30. D’Cruz LM, Lind KC., Wu, B., Fujimoto, J.K., Goldrath AW. Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T cell immune response. European Journal of Immunology. 2012 42(8):2031-41.  [Full Text] [PDF]
     
  31. Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D’Cruz LM, Watowich SS, Murre C, Goldrath AW. The transcriptional regulators Id2 and Id3 control formation of distinct CD8+ memory T cell subsets. Nature Immunology. 2011 12(12):1221-29. [Full Text] [PDF]
     
  32. Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CGK, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, Collman RG, Wherry EJ, Artis D. Innate lymphoid cells promote lung-tissue homeostasis following acute influenza virus. Nature Immunology. 2011 12(11):1045-54. [Full Text] [PDF]
     
  33. Elpek K, Rubinstein MP, Goldrath AW, Turley SJ. Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ra complexes. Proceedings of the National Academy of Sciences. 2010 107(50):21647-52.[Full Text] [PDF]
     
  34. Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, CoussensLM, Karin M, Goldrath AW, Johnson RS. Macrophage expression of hypoxia-induciblefactor-1 alpha suppresses T-cell function and promotes tumor progression. CancerRes. 2010 Oct 1;70(19):7465-75. [Full Text] [PDF]
     
  35. D'Cruz LM, Yang CY, Goldrath AW. Transcriptional regulation of NKT cell development and homeostasis. Curr Opin Immunol. 2010 Apr;22(2):199-205. [Full Text] [PDF]
     
  36. D'Cruz LM, Knell J, Fujimoto JK, Goldrath AW. An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat Immunol. 2010 Mar;11(3):240-9. [Full Text] [PDF]
     
  37. Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I, Kronenberg M, Goldrath AW. Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci U S A. 2009 Nov 7;106(46):19461-6. [Full Text] [PDF]
     
  38. Cheung KP, Yang E, Goldrath AW. Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells. J Immunol. 2009 Sep 1;183(5):3364-72. [Full Text] [PDF]
     
  39. D'Cruz LM, Rubinstein MP, Goldrath AW. Surviving the crash: transitioning from effector to memory CD8+ T cell. Semin Immunol. 2009 Apr;21(2):92-8. Epub 2009 Mar 6. Review. [Full Text] [PDF]
     
  40. Heng TS, Painter MW; Immunological Genome Project Consortium. The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol. 2008 Oct;9(10):1091-4. [Full Text] [PDF]
     
  41. Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008 Nov 1;112(9):3704-12. [Full Text] [PDF]
     
  42. Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol. 2008 Sep;22(9):2038-48. [Full Text] [PDF]
     
  43. Epardaud M, Elpek KG, Rubinstein MP, Yonekura AR, Bellemare-Pelletier A, Bronson R, Hamerman JA, Goldrath AW, Turley SJ. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 2008 Apr 15;68(8):2972-83. [Full Text] [PDF]
     
  44. Proc Natl Acad Sci USA. 2010 Dec 14;107(50):21647-52. Epub 2010 Nov 22. [Full Text] [PDF]
     
  45. Cannarile MA, Lind NA, Rivera R, Sheridan AD, Camfield KA, Wu BB, Cheung KP, Ding Z, Goldrath AW. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat Immunol. 2006 Dec;7(12):1317-25. [Full Text] [PDF]
     
  46. Goldrath AW, Hedrick SM. Central tolerance matters. Immunity. 2005 Aug;23(2):113-4. Review. [Full Text] [PDF] 
     
  47. Goldrath AW, Luckey CJ, Park R, Benoist C, Mathis D. The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci USA 2004 Nov 30; 101(48):16885-90. [Full Text] [PDF] 
     
  48. Goldrath AW, Sivakumar PV, Glaccum M, Kennedy MK, Bevan, MJ, Benoist C, Mathis D, Butz EA. Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med. 2002 Jun 17;195(12):1515-22. [Full Text] [PDF] 
     
  49. Goldrath AW. Maintaining the status quo: T-cell homeostasis. Microbes Infect. 2002 Apr;4(5):539-45. Review. [Full Text] [PDF] 
     
  50. Goldrath AW, Bogatzki LY, Bevan MJ. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med. 2000 Aug 21;192(4):557-64. [Full Text] [PDF] 
     
  51. Bevan MJ, Goldrath AW. T-cell memory: You must remember this ... Curr Biol. 2000 May 4;10(9):R338-40. Review. [Full Text] [PDF] 
     
  52. Goldrath AW, Bevan MJ. Selecting and maintaining a diverse T-cell repertoire. Nature. 1999 Nov 18;402(6759):255-62. Review. [Full Text] [PDF] 
     
  53. Goldrath AW, Bevan MJ. Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity. 1999 Aug;11(2):183-90. [Full Text] [PDF] 
     
  54. Goldrath AW, Hogquist KA, Bevan MJ. CD8 lineage commitment in the absence of CD8. Immunity. 1997 May;6(5):633-42. [Full text] [PDF]